![]() ![]() ![]() Lipids are heterogeneous group of fat and fat soluble substances characterized by being water-insoluble and soluble in nonpolar solvents such as alcohol, ether, chloroform, benzene, etc. 7– 10 Producing reference intervals for a general population is a major challenge, as it requires selecting the appropriate reference population and recruiting individuals who represent relevant demographic groups that meet the inclusion criteria collecting, processing and testing specimens and finally, calculating reference values with possible stratification of the data into subgroups. Reference intervals are typically established by assaying specimens from a sample group of people who meet carefully defined criteria. Reference values may be used to evaluate the state of health of individuals and populations, to identify people at risk for disease, to help in decision making in clinical medicine and to be used for various scientific purposes. In India, reference values used in laboratories have been established in the western population. The central role of the laboratory scientist is to aid the clinician, in interpreting observed values, by providing relevant reference values in a convenient and practical form. Clinicians compare the patient related observation with the reference values and come to a conclusion on the diagnosis of the disease, which help them to treat the patient accurately. It was the International Federation of Clinical Chemistry (IFCC) who came up with the concept of reference interval mainly to avoid the problems with normal values and values obtained from an individual under clinical investigation. Keywords: HDL-C, LDL-C, Lipid profile, Reference interval, Total cholesterol, Triglyceride.Ī reference interval may be the range of values that are deemed normal for physiological measurement of a particular type of quantity in a reference population. Hence this can be considered as the reference interval for this study population, further study is needed in a larger population. ![]() In the age group 39–48 years TC, TG, HDL-C and LDL-C in males were higher as compared to females of that age group.Ĭonclusion: Reference ranges are wider as compared to western standard, which is due to variation in diet, ethnicity, environment, etc. After grouping them according to age and sex, we observed that HDL-C was significantly wider in females compared to males, TC was not significantly wider, but TG was higher in males. We analyzed total cholesterol, triglycerides, HDL-cholesterol by standard methods and, LDL-cholesterol was calculated using Friedewald’s formula. Materials and methods: This is a cross-sectional study, including 200 subjects in total (according to CLSI guidelines). 1 There is no well documented evidence for the establishment of reference levels for lipids parameters for the Indian population, so there is a need for large scale study on lipid profile of Indian population. Clinicians all over the world use these reference values to interpret the results obtained in patients, it should correctly impersonate the defined population having close comparison with the patient coming for investigation. These usually do not have similarity with the Indian population this is seen especially in case of the lipid profile. Indian J Med Biochem 2019 23(3):327–330.Ĭommonly the reference values used in most of the laboratory are based on the western population. ![]() Establishment of Reference Intervals for Fasting and Nonfasting Serum Lipid Profile from Healthy Population in Mangaluru, Karnataka, India. Indian Journal of Medical Biochemistry Volume 23 | Issue 3 | Year 2019Įstablishment of Reference Intervals for Fasting and Nonfasting Serum Lipid Profile from Healthy Population in Mangaluru, Karnataka, Indiaĭeepti S Ireshanavar 1, Sukanya Shetty 2, Ashalatha Rao 3, Vidya S Patil 4, Vijayetha P Patil 5, Alagilwada S Shilpasree 6ġ,4–6Department of Biochemistry, SDM College of Medical Sciences and Hospital, Dharwad, Karnataka, India 2,3Department of Biochemistry, KS Hegde Medical Academy, Mangaluru, Karnataka, IndiaĬorresponding Author: Deepti S Ireshanavar, Department of Biochemistry, SDM College of Medical Sciences and Hospital, Dharwad, Karnataka, India, Phone: +91 9986960051, e-mail: to cite this article Ireshanavar DS, Shetty S, Rao A, et al. ![]()
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